Frequency of Thyroid Dysfunctions in Euthymic Patients with Bipolar Disorder

Introductıon: The association between thyroid dysfunctions and mood disorders has been known for years. This study investigated the frequency of thyroid dysfunctions in euthymic patients with bipolar disorder.

Metarials and Methods: The study group consisted of 38 euthymic patients with bipolar disorder defined by Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria. Blood TSH and T4 levels were retrospectively screened in euthymic episods of the patients with bipolar disorder. This was compared with the similar studies in Turkey

Results: A total of 38 subjects (14 males, 24 females) were included the study, and their mean age was 40,47 years. Mean thyrotropin (TSH) and free T4 levels were 1,87±1,29 μIU/mL and 1,19±0,25 ng/dL respectively. TSH levels were detected outside the normal range in 15.8% of the patients.

Conclusion: These results suggest that the prevalence of high thyroid dysfunction in euthymic episod of patients with bipolar disorder and persists beyond the manic and depressive episodes.

Keywords: Bipolar disorder, thyroid dysfunctions. TSH, euthymic, mood.